World leading glaucoma risk prediction

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Understanding glaucoma risk

Seonix Bio is dedicated to helping health professionals, individuals and researchers understand glaucoma risk using genetics.

Genetic risk
prediction
An individual’s genetic risk of developing glaucoma
Clinically relevant information
Linked to a range of clinically relevant outcomes
World-leading
team
Experienced clinicians, geneticists, and bioinformaticians

Glaucoma

Glaucoma is a group of eye diseases that cause progressive vision loss by damaging the optic nerve. Glaucoma progression is often gradual and individuals may not realise they are losing peripheral vision until  optic nerve damage has occurred1.

Normal vision
Early stage
Intermediate
Advanced

Genetic risk scores

Genetic testing is widely used to assess the risk of diseases caused by changes in a single gene.  However, many diseases – including glaucoma – are polygenic, that is they are influenced by a large number of genetic variants scattered throughout the genome. Genetic risk scores are a powerful new approach that combine the effects of hundreds or thousands of these variants to predict an individual’s disease risk and how it compares to others in a population.

A genetic risk score for glaucoma

We have developed a genetic risk score for glaucoma. Glaucoma is well suited for genetic risk score analysis due to its high heritability. Our approach has been published in world leading journals such as Nature Genetics2 and JAMA Ophthalmology3 and was developed using some of the world’s most extensive glaucoma patient sample collections. It has been associated with a range of clinically relevant measures associated with glaucoma risk.

Our genetic risk score is calculated using a simple, saliva-based testing approach.

Saliva collection
DNA analysis
Genetic risk calculation
Results

A range of applications

Our genetic risk score has a range of potential applications, including for:

  • Individuals to understand their glaucoma risk so they can be proactive about their healthcare.
  • Healthcare professionals to develop preventative risk mitigating strategies for glaucoma, potentially including increased monitoring for those at higher risk to help detect any signs of glaucoma early.
  • Research studies, for example to support pharmaceutical development.

Our genetic risk score is currently available for research use only, with health and clinical applications in development.

References

1. Glaucoma Australia. https://glaucoma.org.au/

2. Craig, J.E et. al (2020). Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nature Genetics.

3. Siggs, O.M. et al. (2021). Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma. JAMA Ophthalmol.

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