World leading glaucoma risk prediction

Understanding glaucoma risk

Seonix Bio is dedicated to helping health professionals, individuals and researchers understand glaucoma risk using genetics.

                                                                                Genetic risk 
 prediction                                                                            

An individual’s genetic risk of developing glaucoma

Clinically relevant information

Linked to a range of clinically relevant outcomes

                                                                                World-leading 
 team                                                                            

Experienced clinicians, geneticists, and bioinformaticians

Glaucoma

Glaucoma is a group of eye diseases that cause progressive vision loss by damaging the optic nerve. Glaucoma progression is often gradual and individuals may not realise they are losing peripheral vision until optic nerve damage has occurred¹.

Normal vision

Early stage

Intermediate

Advanced

Genetic risk scores

Genetic testing is widely used to assess the risk of diseases caused by changes in a single gene.  However, many diseases – including glaucoma – are polygenic, that is they are influenced by a large number of genetic variants scattered throughout the genome. Genetic risk scores are a powerful new approach that combine the effects of hundreds or thousands of these variants to predict an individual’s disease risk and how it compares to others in a population.

A genetic risk score for glaucoma

We have developed a genetic risk score technology platform for glaucoma, called SightScore^TM. Glaucoma is well suited for genetic risk score analysis due to its high heritability. Our approach has been published in world leading journals such as Nature Genetics² and JAMA Ophthalmology³ and was developed using some of the world’s most extensive glaucoma patient sample collections. Our approach has since been significantly improved. It has been associated with a range of clinically relevant measures associated with glaucoma risk.

Our genetic risk score can be calculated using a simple, saliva-based testing approach.

Saliva collection

DNA analysis

Genetic risk calculation

Results

A range of applications

Our SightScore^TM technology platform will initially be offered as a service, and can potentially be used for:

Individuals to understand their glaucoma risk so they can be proactive about their healthcare.
Healthcare professionals to develop preventative risk mitigating strategies for glaucoma, potentially including increased monitoring for those at higher risk to help detect any signs of glaucoma early.
Research studies, for example to support pharmaceutical development.

Our genetic risk score is currently available for research use only, with health and clinical services in development.

References

1. Glaucoma Australia. https://glaucoma.org.au/

2. Craig, J.E et. al (2020). Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nature Genetics.

3. Siggs, O.M. et al. (2021). Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma. JAMA Ophthalmol.